Hrk^tm1Ast
Targeted Allele Detail

Summary

• Symbol: Hrk^tm1Ast
• Name: harakiri, BCL2 interacting protein (contains only BH3 domain); targeted mutation 1, Andreas Strasser
• MGI ID: MGI:3720713
• Synonyms: Hrk^-
• Gene: Hrk Location: Chr5:118307829-118327543 bp, + strand Genetic Position: Chr5, 58.16 cM, cytoband F
• Alliance: Hrk^tm1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124044
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon was replaced with a reporter gene that encodes NLS-betagal with a floxed neo cassette. The neo was subsequently removed via cre mediated recombination. Absence of transcript was confirmed in Northern blot or RT-PCR. (J:124044)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrk Mutation: 0 strains or lines available

References

• Original: J:124044 Coultas L, et al., Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. J Cell Sci. 2007 Jun 15;120(Pt 12):2044-52
• All: 2 reference(s)