Tg(Itgax-cre,-EGFP)4097Ach
Transgene Detail

Summary

• Symbol: Tg(Itgax-cre,-EGFP)4097Ach
• Name: transgene insertion 4097, Alexander V Chervonsky
• MGI ID: MGI:3720729
• Synonyms: CD11c-Cre, CD11c-Cre 4907, CD11c-Cre-GFP, CD11c-Cre-GFP.4097, Tg(Itgax-cre,EGFP)4097Ach
• Transgene: Tg(Itgax-cre,-EGFP)4097Ach Location: unknown
• Alliance: Tg(Itgax-cre,-EGFP)4097Ach page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Itgax-cre,-EGFP)4097Ach expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Itgax

• Mutation details: The Itgax promoter and enchancer were used to drive cre expression in a pIRES2-EGFP-based plasmid. Two lines were created with line 4097 exhibiting greater expression than 4272 in dendritic cells. (J:123556)

Recombinase activity

Activity:	Tissue activity of this recombinase allele MGI has not yet included tissue activity data for this allele in any anatomical systems.
Driver:	Itgax (species not specified) Summary of all recombinase alleles driven by Itgax.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach/0	B6NTac.Cg-Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
cn2	Cd1d1^tm1.1Aben/Cd1d1^tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach/0	C57BL/6-Cd1d1^tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach
cn3	Abca1^tm1Jp/Abca1^tm1Jp Abcg1^tm1Tall/Abcg1^tm1Tall Tg(Itgax-cre,-EGFP)4097Ach/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
cn4	Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Tg(Itgax-cre,-EGFP)4097Ach/?	involves: C57BL/6J * C57BL/6NTac
cn5	Fas^tm1Ach/Fas^tm1Ach Tg(Itgax-cre,-EGFP)4097Ach/?	Not Specified

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5
show or hide all annotated terms
adipose tissue				√
decreased total fat pad weight				√
cellular					√
decreased apoptosis					√
digestive/alimentary system				√
abnormal gut flora balance				√
growth/size/body					√
enlarged spleen					√
hematopoietic system			√		√
abnormal bone marrow cell morphology/development			√
increased dendritic cell number					√
abnormal spleen morphology					√
enlarged spleen					√
abnormal spleen periarteriolar lymphoid sheath morphology					√
increased immunoglobulin level					√
increased IgG level					√
increased IgM level					√
immune system	√	√	√	N	√
immune system phenotype		N		N
increased dendritic cell number					√
abnormal spleen morphology					√
enlarged spleen					√
abnormal spleen periarteriolar lymphoid sheath morphology					√
increased immunoglobulin level					√
increased IgG level					√
increased IgM level					√
decreased interferon-gamma secretion	√	√
decreased interleukin-12b secretion	√
increased interleukin-17 secretion			√
increased interleukin-23 secretion			√
decreased interleukin-4 secretion		√
increased anti-nuclear antigen antibody level					√
increased susceptibility to bacterial infection	√
increased susceptibility to bacterial infection induced morbidity/mortality	√
liver/biliary system					√
abnormal liver morphology					√
mortality/aging	√
increased susceptibility to bacterial infection induced morbidity/mortality	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available

Notes

Two lines were created with line 4097 exhibiting greater expression than 4272 in dendritic cells.

References

• Original: J:123556 Stranges PB, et al., Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007 May;26(5):629-41
• All: 99 reference(s)