Gab1^tm1Nmoc
Targeted Allele Detail

Summary

• Symbol: Gab1^tm1Nmoc
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Naoki Mochizuki
• MGI ID: MGI:3720732
• Synonyms: Gab1^flox
• Gene: Gab1 Location: Chr8:81491067-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm1Nmoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124033
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2, which encodes part of the pleckstrin homology domain. A floxed neo was removed via transient transfection of a cre recombinase plasmid. (J:124033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 78 strains or lines available

References

• Original: J:124033 Nakaoka Y, et al., Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J Clin Invest. 2007 Jul;117(7):1771-81
• All: 4 reference(s)