Cpa1^{tm1(cre/ERT2)Dam}
Targeted Allele Detail

Summary

• Symbol: Cpa1^{tm1(cre/ERT2)Dam}
• Name: carboxypeptidase A1, pancreatic; targeted mutation 1, Douglas A Melton
• MGI ID: MGI:3720733
• Synonyms: Cp1aCreER^T2, Cpa1^{tm1(cre/ESR1)Dam}, proCPA1CreER^T2
• Gene: Cpa1 Location: Chr6:30639217-30645360 bp, + strand Genetic Position: Chr6, 12.52 cM, cytoband B1
• Alliance: Cpa1^{tm1(cre/ERT2)Dam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123923
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cpa1^{tm1(cre/ERT2)Dam} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cpa1 (MGI:88478)

• Mutation details: A CreERT2-IRES-H2BYFP-ACN cassette was inserted into the locus to replace the first 11 amino acids of the coding region. (J:123923)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cpa1 (mouse) Summary of all recombinase alleles driven by Cpa1. Comparative matrix view of recombinase activities Alliance mouse Cpa1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpa1 Mutation: 25 strains or lines available

References

• Original: J:123923 Zhou Q, et al., A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14
• All: 2 reference(s)