Ctla4^tm1Yliu
Targeted Allele Detail

Summary

• Symbol: Ctla4^tm1Yliu
• Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1, Yang Liu
• MGI ID: MGI:3720741
• Synonyms: CTLA4^h
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^tm1Yliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123940
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: The human CTLA4 exons 2 and 3 were inserted into the locus to replace endogenous exons 2 and 3. These exons encode the extracellular and transmembrane domains. A floxed neo was subsequently removed via transient cre expression. (J:123940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 54 strains or lines available

References

• Original: J:123940 Lute KD, et al., Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. Blood. 2005 Nov 1;106(9):3127-33
• All: 4 reference(s)