Bmal1^tm1Weit
Targeted Allele Detail

Summary

• Symbol: Bmal1^tm1Weit
• Name: basic helix-loop-helix ARNT like 1; targeted mutation 1, Charles Weitz
• MGI ID: MGI:3720808
• Synonyms: Bmal1^lox, Bmal^f, conditional Bmal
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^tm1Weit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124157
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Using homologous recombination in a bacterial artificial chromosome (BAC, clone RPCI23-331K23), an FRT-flanked neo cassette (followed by a loxP site) was inserted immediately downstream of exon 8 of the targeted gene. An additional loxP site was added upstream of exon 8 when the targeting vector was excised from the BAC. Correctly targeted ES cells were injected into blastocysts and chimeric mice were bred to Flpe-expressing mice to excise the neo cassette. (J:124157)

Expression

In Mice Carrying this Mutation:

18 assay results 15 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Bmal1^tm1Weit

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 139 strains or lines available

References

• Original: J:124157 Storch KF, et al., Intrinsic circadian clock of the Mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24;130(4):730-41
• All: 186 reference(s)