Prkci^tm1Rfar
Targeted Allele Detail

Summary

• Symbol: Prkci^tm1Rfar
• Name: protein kinase C, iota; targeted mutation 1, Robert V Farese Sr
• MGI ID: MGI:3720810
• Synonyms: aPKClambda^fl, PKClambda^fl, PKClambda/iota, Prkci^tm1Far, Prkci^tm1Rvf
• Gene: Prkci Location: Chr3:31049893-31106889 bp, + strand Genetic Position: Chr3, 14.65 cM
• Alliance: Prkci^tm1Rfar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123964
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exon containing nucleotides 110-233 (exon 2) was flanked by loxP sites. A neomycin resistance cassette was inserted downstream of the exon. (J:87746)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkci Mutation: 69 strains or lines available

References

• Original: J:123964 Farese RV, et al., Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest. 2007 Aug;117(8):2289-301
• All: 26 reference(s)