Siglec1^{tm1(HBEGF)Mtka}
Targeted Allele Detail

Summary

• Symbol: Siglec1^{tm1(HBEGF)Mtka}
• Name: sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 1, Masato Tanaka
• MGI ID: MGI:3720841
• Synonyms: CD169-DTR, CD169^DTR
• Gene: Siglec1 Location: Chr2:130911140-130928685 bp, - strand Genetic Position: Chr2, 63.26 cM, cytoband F-H1
• Alliance: Siglec1^{tm1(HBEGF)Mtka} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123958
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Siglec1^{tm1(HBEGF)Mtka} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A 28-bp fragment including the endogenous ATG in exon 1 was replaced with human heparin-binding EGF-like growth factor and a floxed neo cassette. (J:123958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Siglec1 Mutation: 84 strains or lines available

References

• Original: J:123958 Miyake Y, et al., Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest. 2007 Aug;117(8):2268-78
• All: 67 reference(s)