Atf7^tm1Nicj
Targeted Allele Detail

Summary

• Symbol: Atf7^tm1Nicj
• Name: activating transcription factor 7; targeted mutation 1, Nic Jones
• MGI ID: MGI:3720869
• Synonyms: Atf7^-
• Gene: Atf7 Location: Chr15:102434381-102533899 bp, - strand Genetic Position: Chr15, 57.66 cM, cytoband F3
• Alliance: Atf7^tm1Nicj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert an IRES-lacZ-pA and floxed neo into the locus, replacing part of exon 10 which encodes the basic region DNA binding domain and part of the leucine zipper dimerization domain. (J:123909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf7 Mutation: 61 strains or lines available

References

• Original: J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
• All: 3 reference(s)