F12^tm1Pbfd
Targeted Allele Detail

Summary

• Symbol: F12^tm1Pbfd
• Name: coagulation factor XII (Hageman factor); targeted mutation 1, Peter Burfiend
• MGI ID: MGI:3720935
• Synonyms: FXII^-
• Gene: F12 Location: Chr13:55565771-55574606 bp, - strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: F12^tm1Pbfd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin resistance cassette. Northern blot analysis confirmed absence of protein in mutant mice. (J:124154)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F12 Mutation: 29 strains or lines available

References

• Original: J:124154 Pauer HU, et al., Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo. Thromb Haemost. 2004 Sep;92(3):503-8
• All: 16 reference(s)