C5ar2^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: C5ar2^tm1Gdy
• Name: complement component 5a receptor 2; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:3721065
• Synonyms: C5L2 KO, VG100
• Gene: C5ar2 Location: Chr7:15968512-15978079 bp, - strand Genetic Position: Chr7, 8.77 cM
• Alliance: C5ar2^tm1Gdy page

Hepatic steatosis in C3^tm1Crr/C3^tm1Crr and C5ar2^tm1Gdy/C5ar2^tm1Gdy mice following partial hepatectomy

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102090
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Velocigene technology was used to delete a 1 kb portion of the gene and introduce a lacZ reporter gene. (J:102090)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C5ar2 Mutation: 21 strains or lines available

References

• Original: J:102090 Valenzuela DM, et al., High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol. 2003 Jun;21(6):652-9
• All: 6 reference(s)