Capn10^tm1Ksp
Targeted Allele Detail

Summary

• Symbol: Capn10^tm1Ksp
• Name: calpain 10; targeted mutation 1, Kenneth S Polonsky
• MGI ID: MGI:3721096
• Synonyms: Capn10^-
• Gene: Capn10 Location: Chr1:92862130-92875670 bp, + strand Genetic Position: Chr1, 46.6 cM
• Alliance: Capn10^tm1Ksp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123988
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete exon 2. The vector included the self excising ACN cassette. Western blot confirmed absence of protein in mutants. (J:123988)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Capn10 Mutation: 26 strains or lines available

References

• Original: J:123988 Johnson JD, et al., RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem. 2004 Jun 4;279(23):24794-802
• All: 1 reference(s)