Itgb3^tm2Mgin
Targeted Allele Detail

Summary

• Symbol: Itgb3^tm2Mgin
• Name: integrin beta 3; targeted mutation 2, Mark H Ginsberg
• MGI ID: MGI:3721109
• Synonyms: Beta3(L746A)
• Gene: Itgb3 Location: Chr11:104498826-104561302 bp, + strand Genetic Position: Chr11, 67.84 cM
• Alliance: Itgb3^tm2Mgin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123968
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The L746A mutation was inserted into exon 15. A floxed neo was subsequently removed via cre mediated recombination. (J:123968)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb3 Mutation: 45 strains or lines available

References

• Original: J:123968 Petrich BG, et al., The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug;117(8):2250-9
• All: 4 reference(s)