Egfl7^tm1Wye
Targeted Allele Detail

Summary

• Symbol: Egfl7^tm1Wye
• Name: EGF-like domain 7; targeted mutation 1, Weilan Ye
• MGI ID: MGI:3721404
• Gene: Egfl7 Location: Chr2:26471095-26482694 bp, + strand Genetic Position: Chr2, 18.95 cM, cytoband B
• Alliance: Egfl7^tm1Wye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-7 were replaced by a lacZ gene and a PGK-Neo selection cassette. LacZ staining was seen in endothelial cells of E10.5 heterozygous mice. Immunofluorescence staining failed to detect protein in the uterus of pregnant homozygous mice. (J:124110)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egfl7 Mutation: 17 strains or lines available

References

• Original: J:124110 Schmidt M, et al., EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007 Aug;134(16):2913-23
• All: 1 reference(s)