Helt^tm1Yono
Targeted Allele Detail

Summary

• Symbol: Helt^tm1Yono
• Name: helt bHLH transcription factor; targeted mutation 1, Yuichi Ono
• MGI ID: MGI:3721409
• Gene: Helt Location: Chr8:46745076-46747708 bp, - strand Genetic Position: Chr8, 26.32 cM
• Alliance: Helt^tm1Yono page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124115
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 were replaced by a GFP gene and a neomycin selection cassette. No gene expression was detected in homozygous embryos. GFP expression recapitulated endogenous gene expression. (J:124115)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Helt Mutation: 9 strains or lines available

References

• Original: J:124115 Nakatani T, et al., Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development. 2007 Aug;134(15):2783-93
• All: 1 reference(s)