Tshz1^tm1Core
Targeted Allele Detail

Summary

• Symbol: Tshz1^tm1Core
• Name: teashirt zinc finger family member 1; targeted mutation 1, Nathalie Core
• MGI ID: MGI:3721421
• Gene: Tshz1 Location: Chr18:84029752-84105831 bp, - strand Genetic Position: Chr18, 57.53 cM
• Alliance: Tshz1^tm1Core page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124124
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 was replaced with a EGFP gene and a neomycin selection cassette. No gene expression was detected by in site hybridization in embryos at mid embryogenesis. EGFP protein was not detected due to a mutation that prematurely inserted a stop codon. (J:124124)

Expression

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshz1 Mutation: 52 strains or lines available

References

• Original: J:124124 Core N, et al., Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev Biol. 2007 Aug 15;308(2):407-20
• All: 2 reference(s)