C8b⁰
Spontaneous Allele Detail

Summary

• Symbol: C8b⁰
• Name: complement component 8, beta polypeptide; deficient
• MGI ID: MGI:3721517
• Gene: C8b Location: Chr4:104623514-104661745 bp, + strand Genetic Position: Chr4, 48.61 cM
• Alliance: C8b⁰ page

Mutation origin

• Strain of Origin: Mae or MSM/Ms

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: A screen of sera from mice of 73 strains for deficiencies in complement-mediated lysis of antibody-primed rabbit or sheep erythrocytes identified two strains, of 8 derived from the wild hybrid species M. m. molossinus, lacking lytic activity. Their hemolytic activity was restored by addition of partially purified human complement factor 8 or of human serum depleted of C8alpha and C8gamma. The gene responsible in strain MSM/Ms was mapped to the region of the mouse genome sharing synteny with the chromosomal location of human C8B. Combined sera from the two deficient strains also lacked hemolytic activity. (J:11000)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C8b Mutation: 35 strains or lines available

Notes

Two sublines of Mae were derived, one deficient in C8beta activity and the other having normal hemolytic activity. The authors state that the female founder of the stock was heterozygous for the inactivating mutation. (J:11000)

References

• Original: J:11000 Tanaka S, et al., Gene responsible for deficient activity of the beta subunit of C8, the eighth component of complement, is located on mouse chromosome 4. Immunogenetics. 1991;33(1):18-23
• All: 1 reference(s)