Femwf1^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Femwf1^MRL/MpJ
• Name: femur work to failure 1; MRL/MpJ
• MGI ID: MGI:3721601
• QTL: Femwf1 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:123467

Linkage analysis was performed on 633 (MRL/MpJ x SJL/J)F2 female animals at 7 weeks of age to identify genetic loci associated with femur work to failure. A panel of 119 polymorphic markers spaced 12 cM apart was used for genome scan. Parental strain MRL/MpJ displays significantly increased work to failure values compared to parental strain SJL/J. A total of 5 significant QTLs and 1 suggestive QTL were mapped and accounted for 20.7% of the phenotypic variance. After adjusting for periosteal circumference, the 5 major QTLs retained significant association to femur work to failure.

Significant linkage to femur work to failure mapped to 54.6 cM on mouse Chromosome 2 near D2Mit62 (LOD=8.4). This locus accounts for 7.1% of the variance and overlaps with femur breaking strength QTL Fembrs1. A potential candidate gene for Fembrs1 is Fmn1 at 65 cM.

Curator Note 12.30.2014: We have named this femur work to failure QTL mapping to Chr 2 near D2Mit62 (LOD=8.4) as Femwf14, to identify it as a significant and unique QTL.

A novel QTL was detected at 14.4 cM on mouse Chromosome X near DXMit208 (LOD=3.8). This locus accounts for 3.3% of the variance and is named Femwf1 (femur work to failure 1).

Significant linkage to femur work to failure mapped to 20.7 cM on mouse Chromosome 8 near D8Mit125 (LOD=3.7) and colocalizes with Fembrs2. This QTL explains 2.9% of the phenotypic variance.

Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 8 as Femwf15, to identify it as a significant and unique QTL.

A novel QTL for femur work to failure was identified at 31.2 cM on mouse Chromosome 7 near D7Mit232 (LOD=2.8). This locus explains 2.8% of the variance and is named Femwf2 (femur work to failure 2).

Significant linkage to femur work to failure mappedto 46.5 cM on mouse Chromosome9 near D9Mit270 (LOD=2.1). This locus explains 1.8% of the variance and colocalizes with bone mineral density QTL Bmd10 (48 cM).

Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 9 as Femwf16, to identify it as a significant and unique QTL.

Suggestive linkage to femur work to failure mapped to 6.6 cM on mouse Chromosome 17 (LOD=2.1). This locus colocalizes with femur breaking strength QTL Fembrs4.

Several interacting loci were also detected by 2-way analysis. Femwf3 (51 cM, D10Mit95) on mouse Chromosome 10 interacts with Femwf4 (47.5 cM, D2Mit44), Femwf5 (49.8 cM, D7Mit44), and Femwf6 (47.6 cM, D11Mit36). These interactions explain 8.9% of the variance.

Femwf7 (101.5 cM, D1Mit291) on mouse Chromosome 1 interacts with Femwf8(15 cM, D7Mit246) and Femwf9 (2 cM, D12Mit182). These interactions explain 7.3% of the variance.

Femwf10 (15.4 cM, D15Mit138) on mouseChromosome 15 interacts with Femwf11 (43 cM, D19Mit53) on mouse Chromosome 19. This interaction explains 3.1% of the variance.

Femwf12 (81.6 cM,D1Mit33) on mouse Chromosome 1 interacts with Femwf13 (61.9 cM, D4Mit204) on mouse Chromosome 4. This interaction explains 3.4% of the variance.

References

• Original: J:123467 Li X, et al., Chromosomal regions harboring genes for the work to femur failure in mice. Funct Integr Genomics. 2002 Apr;1(6):367-74
• All: 1 reference(s)