Femwf3^SJL/J
QTL Variant Detail

Summary

• QTL variant: Femwf3^SJL/J
• Name: femur work to failure 3; SJL/J
• MGI ID: MGI:3721606
• QTL: Femwf3 Location: Chr10:92338568-92338767 bp Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: SJL/J

Variant description

• Allele Type: QTL

Notes

This QTL interacts with Femwf4 on chromosome 2, Femwf5 on chromosome 7, and Femwf6 on chromosome 11.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:123467

Linkage analysis was performed on 633 (MRL/MpJ x SJL/J)F2 female animals at 7 weeks of age to identify genetic loci associated with femur work to failure. A panel of 119 polymorphic markers spaced 12 cM apart was used for genome scan. Parental strain MRL/MpJ displays significantly increased work to failure values compared to parental strain SJL/J. A total of 5 significant QTLs and 1 suggestive QTL were mapped and accounted for 20.7% of the phenotypic variance. After adjusting for periosteal circumference, the 5 major QTLs retained significant association to femur work to failure.

Significant linkage to femur work to failure mapped to 54.6 cM on mouse Chromosome 2 near D2Mit62 (LOD=8.4). This locus accounts for 7.1% of the variance and overlaps with femur breaking strength QTL Fembrs1. A potential candidate gene for Fembrs1 is Fmn1 at 65 cM.

Curator Note 12.30.2014: We have named this femur work to failure QTL mapping to Chr 2 near D2Mit62 (LOD=8.4) as Femwf14, to identify it as a significant and unique QTL.

A novel QTL was detected at 14.4 cM on mouse Chromosome X near DXMit208 (LOD=3.8). This locus accounts for 3.3% of the variance and is named Femwf1 (femur work to failure 1).

Significant linkage to femur work to failure mapped to 20.7 cM on mouse Chromosome 8 near D8Mit125 (LOD=3.7) and colocalizes with Fembrs2. This QTL explains 2.9% of the phenotypic variance.

Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 8 as Femwf15, to identify it as a significant and unique QTL.

A novel QTL for femur work to failure was identified at 31.2 cM on mouse Chromosome 7 near D7Mit232 (LOD=2.8). This locus explains 2.8% of the variance and is named Femwf2 (femur work to failure 2).

Significant linkage to femur work to failure mappedto 46.5 cM on mouse Chromosome9 near D9Mit270 (LOD=2.1). This locus explains 1.8% of the variance and colocalizes with bone mineral density QTL Bmd10 (48 cM).

Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 9 as Femwf16, to identify it as a significant and unique QTL.

Suggestive linkage to femur work to failure mapped to 6.6 cM on mouse Chromosome 17 (LOD=2.1). This locus colocalizes with femur breaking strength QTL Fembrs4.

Several interacting loci were also detected by 2-way analysis. Femwf3 (51 cM, D10Mit95) on mouse Chromosome 10 interacts with Femwf4 (47.5 cM, D2Mit44), Femwf5 (49.8 cM, D7Mit44), and Femwf6 (47.6 cM, D11Mit36). These interactions explain 8.9% of the variance.

Femwf7 (101.5 cM, D1Mit291) on mouse Chromosome 1 interacts with Femwf8(15 cM, D7Mit246) and Femwf9 (2 cM, D12Mit182). These interactions explain 7.3% of the variance.

Femwf10 (15.4 cM, D15Mit138) on mouseChromosome 15 interacts with Femwf11 (43 cM, D19Mit53) on mouse Chromosome 19. This interaction explains 3.1% of the variance.

Femwf12 (81.6 cM,D1Mit33) on mouse Chromosome 1 interacts with Femwf13 (61.9 cM, D4Mit204) on mouse Chromosome 4. This interaction explains 3.4% of the variance.

References

• Original: J:123467 Li X, et al., Chromosomal regions harboring genes for the work to femur failure in mice. Funct Integr Genomics. 2002 Apr;1(6):367-74
• All: 1 reference(s)