Shb^tm1.1Miwe
Targeted Allele Detail

Summary

• Symbol: Shb^tm1.1Miwe
• Name: src homology 2 domain-containing transforming protein B; targeted mutation 1.1, Michael Welsh
• MGI ID: MGI:3721903
• Gene: Shb Location: Chr4:45423278-45530804 bp, - strand Genetic Position: Chr4, 24.0 cM
• Alliance: Shb^tm1.1Miwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124188
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1. Homozygous mice did not express any of the target protein in the liver or kidney as determined by western blotting. (J:117357)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shb Mutation: 31 strains or lines available

References

• Original: J:124188 Kriz V, et al., Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Dev Dyn. 2007 Sep;236(9):2485-92
• All: 10 reference(s)