Egfl7^{Gt(OST80956)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Egfl7^{Gt(OST80956)Lex}
• Name: EGF-like domain 7; gene trap OST80956, Lexicon Genetics
• MGI ID: MGI:3721958
• Gene: Egfl7 Location: Chr2:26471095-26482694 bp, + strand Genetic Position: Chr2, 18.95 cM, cytoband B
• Alliance: Egfl7^{Gt(OST80956)Lex} page

Mutation origin

• Mutant Cell Line: OST80956
• Germline Transmission: Earliest citation of germline transmission: J:124110
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Vector insertion occurred in intron 2, upstream of the translation initation codon in exon 3. Disruption of endogenous gene transcription was confirmed by RT-PCR from spleen and kidney. (J:124110)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST80956	CG518742 ; (MGI Seq Detail)	3' RACE	Chr2:26479054-26480763 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egfl7 Mutation: 17 strains or lines available

References

• Original: J:124110 Schmidt M, et al., EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007 Aug;134(16):2913-23
• All: 6 reference(s)