Esam^tm1Dvst
Targeted Allele Detail

Summary

• Symbol: Esam^tm1Dvst
• Name: endothelial cell-specific adhesion molecule; targeted mutation 1, Dietmar Vestweber
• MGI ID: MGI:3722082
• Synonyms: Esam^-
• Gene: Esam Location: Chr9:37439385-37449615 bp, + strand Genetic Position: Chr9, 20.77 cM, cytoband B
• Alliance: Esam^tm1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124397
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequences of exons 1 and 2 were replaced by a neomycin resistance cassette. Protein was undetectable in mutant mice. (J:124397)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esam Mutation: 22 strains or lines available

References

• Original: J:124397 Wegmann F, et al., ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med. 2006 Jul 10;203(7):1671-7
• All: 2 reference(s)