Nod2^tm1Jhgt
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1Jhgt
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Jean-Pierre Hugot
• MGI ID: MGI:3722087
• Synonyms: Card15/Nod2^-, Nod2^-
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1Jhgt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon carrying the majority of the sequence encoding the CARD domains, including the start codon, was replaced with an EGFP cassette. A PGK-hygromycin cassette included in the vector was removed via cre mediated recombination. (J:124575)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:124575 Barreau F, et al., CARD15/NOD2 is required for Peyer's patches homeostasis in mice. PLoS One. 2007;2(6):e523
• All: 30 reference(s)