Tg(GSK3B*S9A)1Vln
Transgene Detail

Summary

• Symbol: Tg(GSK3B*S9A)1Vln
• Name: transgene insertion 1, Fred Fan Leuven
• MGI ID: MGI:3722095
• Synonyms: GSK-3B(S9A)
• Transgene: Tg(GSK3B*S9A)1Vln Location: unknown
• Alliance: Tg(GSK3B*S9A)1Vln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GSK3B*S9A)1Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GSK3B (2932)

  Gsk3b

  (MGI:1861437)

• Mutation details: DNA coding for human GSK-3B(S9A) was ligated into a vector based on the mouse Thy1 gene and was microinjected into 0.5-day old FVB/N prenuclear mouse embryos. Expression of human GSK3B protein was demonstrated by Western blot in the brain and spinal cord of the mice. (J:100971)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100971 Spittaels K, et al., Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem. 2000 Dec 29;275(52):41340-9
• All: 9 reference(s)