Ccnd1^tm2Phin
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm2Phin
• Name: cyclin D1; targeted mutation 2, Philip W Hinds
• MGI ID: MGI:3722105
• Synonyms: deltaLxCxE
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm2Phin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124353
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was created to engineer a deletion into exon 1 such that 15 nucleotides encoding the LxCxE domain were removed. A floxed neo cassette was inserted into intron 1. (J:124353)

Expression

In Mice Carrying this Mutation:

31 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 22 strains or lines available

References

• Original: J:124353 Landis MW, et al., The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development. Cancer Res. 2007 Aug 15;67(16):7613-20
• All: 1 reference(s)