Nmur1^tm1Rtor
Targeted Allele Detail

Summary

• Symbol: Nmur1^tm1Rtor
• Name: neuromedin U receptor 1; targeted mutation 1, Richard Torres
• MGI ID: MGI:3722111
• Synonyms: VG221
• Gene: Nmur1 Location: Chr1:86313964-86317083 bp, - strand Genetic Position: Chr1, 43.94 cM, cytoband C5
• Alliance: Nmur1^tm1Rtor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124469
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ gene and a floxed neomycin selection cassette were inserted in frame after amino acid 17, deleting sequences encoding amino acids 18 through 387. Quantitative RT- PCR on lung tissue failed to detect endogenous gene expression in homozygous mice. LacZ expression was not detected in homozygous mice. (J:102090, J:124469)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmur1 Mutation: 22 strains or lines available

References

• Original: J:124469 Torres R, et al., Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 2007 Aug;130(3):267-78
• All: 3 reference(s)