Nmur2^tm1Rtor
Targeted Allele Detail

Summary

• Symbol: Nmur2^tm1Rtor
• Name: neuromedin U receptor 2; targeted mutation 1, Richard Torres
• MGI ID: MGI:3722114
• Gene: Nmur2 Location: Chr11:55915816-55931813 bp, - strand Genetic Position: Chr11, 33.39 cM
• Alliance: Nmur2^tm1Rtor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124469
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ gene and a floxed neomycin selection cassette were inserted in frame after the ATG initiation codon, deleting sequences encoding amino acids 2 through 305. Quantitative RT- PCR on spinal cord tissue failed to detect endogenous gene expression in homozygous mice. LacZ expression was detected in numerous tissues of the homozygous mice. (J:124469)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmur2 Mutation: 28 strains or lines available

References

• Original: J:124469 Torres R, et al., Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 2007 Aug;130(3):267-78
• All: 2 reference(s)