Traf3^tm1Bshp
Targeted Allele Detail

Summary

• Symbol: Traf3^tm1Bshp
• Name: TNF receptor-associated factor 3; targeted mutation 1, Gail A Bishop
• MGI ID: MGI:3722126
• Synonyms: Traf3^flox
• Gene: Traf3 Location: Chr12:111132804-111233587 bp, + strand Genetic Position: Chr12, 60.94 cM, cytoband F
• Alliance: Traf3^tm1Bshp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124329
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the first two coding exons of the locus. An frt-flanked neo was included in the vector and subsequently removed by crossing with FLP deleter mice. (J:124329)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Traf3^tm1Bshp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf3 Mutation: 42 strains or lines available

References

• Original: J:124329 Xie P, et al., Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity. 2007 Aug;27(2):253-67
• All: 25 reference(s)