Summary |
|
|||||||||||||
Mutation origin |
||||||||||||||
Mutation description |
|
|||||||||||||
Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
|
|||||||||||||
Find Mice (IMSR) |
|
|||||||||||||
Notes |
Peritoneal macrophages from homozygous mice produce no type I interferon (IFN), and reduced amounts of tumor necrosis factor (TNF)-alpha in response to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand. Homozygous macrophages produce normal levels of type I IFN in response to poly I:C (TLR3 ligand).
|
|||||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/22/2024 MGI 6.24 |
|
|