Summary |
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Mutation origin |
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Mutation description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Find Mice (IMSR) |
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Notes |
Peritoneal macrophages from homozygous mice produce no type I interferon (IFN), and reduced amounts of tumor necrosis factor (TNF)-alpha in response to lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand. Homozygous macrophages produce normal levels of type I IFN in response to poly I:C (TLR3 ligand).
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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