Tg(Thy1-BACE1)16Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-BACE1)16Vln
• Name: transgene insertion 16, Fred Van Leuven
• MGI ID: MGI:3722132
• Synonyms: BACE
• Transgene: Tg(Thy1-BACE1)16Vln Location: unknown
• Alliance: Tg(Thy1-BACE1)16Vln page

Transgene origin

• Strain of Origin: C57BL/6 and DBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-BACE1)16Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BACE1 (23621)

  Bace1

  (MGI:1346542)

• Mutation details: A construct containing the human BACE1 cDNA inserted in the mouse Thy1 gene cassette in the pTSC plasmid was microinjected into day 0.5 pronuclear DBA/C57BL/6 embryos. 5 founders were generated and line 16 was found to have high human BACE1 expression by Western blot. Line 16 was established for further use and characterization. (J:93635)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93635 Willem M, et al., beta-Site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. Am J Pathol. 2004 Nov;165(5):1621-31
• All: 3 reference(s)