Cyld^tm1Jdgl
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1Jdgl
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Jian-Dong Li
• MGI ID: MGI:3722146
• Synonyms: Cyld^-
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1Jdgl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with an IRES-lacZ/MC1-neo cassette. Absence of wild-type transcript was confirmed by RT-PCR. (J:124327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 44 strains or lines available

References

• Original: J:124327 Lim JH, et al., Tumor Suppressor CYLD Regulates Acute Lung Injury in Lethal Streptococcus pneumoniae Infections. Immunity. 2007 Aug;27(2):349-60
• All: 7 reference(s)