Nlrc4^tm1Gln
Targeted Allele Detail

Summary

• Symbol: Nlrc4^tm1Gln
• Name: NLR family, CARD domain containing 4; targeted mutation 1, Jorge E Galan
• MGI ID: MGI:3722152
• Synonyms: ipaf^-
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^tm1Gln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124378
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector inserted the IRES/nls-lacZ/MC1neo cassette to replace exons 2 and 3. RT-PCR confirmed absence of transcript in mutants. (J:124378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 69 strains or lines available

References

• Original: J:124378 Lara-Tejero M, et al., Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12;203(6):1407-12
• All: 40 reference(s)