Diaph1^tm1Asal
Targeted Allele Detail

Summary

• Symbol: Diaph1^tm1Asal
• Name: diaphanous related formin 1; targeted mutation 1, Arthur S Alberts
• MGI ID: MGI:3722153
• Synonyms: Drf1^-, mDia1^-
• Gene: Diaph1 Location: Chr18:37976654-38068529 bp, - strand Genetic Position: Chr18, 19.71 cM
• Alliance: Diaph1^tm1Asal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124643
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The insertion of an EGFP-PGK-neo replaced parts of exons 2 and 6, and all of exons 3-5. (J:124319, J:124643)

Expression

In Mice Carrying this Mutation:	9 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Diaph1 Mutation: 116 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Myeloproliferative syndrome and Myelodysplastic syndrome (J:124643, J:214460)

References

• Original: J:124643 Peng J, et al., Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. Curr Biol. 2003 Apr 1;13(7):534-45
• All: 18 reference(s)