Cd79b^tm1Gzmn
Targeted Allele Detail

Summary

• Symbol: Cd79b^tm1Gzmn
• Name: CD79B antigen; targeted mutation 1, Anna Gazumyan
• MGI ID: MGI:3722155
• Synonyms: IgbetaAA
• Gene: Cd79b Location: Chr11:106202167-106205388 bp, - strand Genetic Position: Chr11, 68.89 cM
• Alliance: Cd79b^tm1Gzmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124400
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Tyrosines 195 and 206 were replaced with alanines. A floxed neo was included in the vector and subsequently removed via cre mediated recombination. (J:124400)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd79b Mutation: 36 strains or lines available

References

• Original: J:124400 Gazumyan A, et al., Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. J Exp Med. 2006 Jul 10;203(7):1785-94
• All: 2 reference(s)