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Tg(Pgk1-FGF2)48Cofn
Transgene Detail
Summary
Symbol: Tg(Pgk1-FGF2)48Cofn
Name: transgene insertion 48, J Douglas Coffin
MGI ID: MGI:3722188
Synonyms: TgFGF214-48
Transgene: Tg(Pgk1-FGF2)48Cofn  Location: unknown  
Alliance: Tg(Pgk1-FGF2)48Cofn page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pgk1-FGF2)48Cofn expresses 1 gene
 
Mutation detailsHuman FGF2 cDNA including the coding sequences for all three CUG and the AUG translational start coding sequences was put under control of a constitutive phosphoglycerate kinase promoter. The Pgk1 polyadenylation sequence was also included in the construct. The construct was microinjected into pronuclear FVB/N oocytes. Production of human FGF2 protein was verified by Western blot. Founder lines with stable copy number and transmission of the transgene were identified and line 48 was established. (J:33064)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:33064 Coffin JD, et al., Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell. 1995 Dec;6(12):1861-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory