Tg(Pgk1-FGF2)48Cofn
Transgene Detail
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Symbol: |
Tg(Pgk1-FGF2)48Cofn |
Name: |
transgene insertion 48, J Douglas Coffin |
MGI ID: |
MGI:3722188 |
Synonyms: |
TgFGF214-48 |
Transgene: |
Tg(Pgk1-FGF2)48Cofn Location: unknown
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Alliance: |
Tg(Pgk1-FGF2)48Cofn page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Pgk1-FGF2)48Cofn expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
FGF2 (2247) |
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Mutation details: Human FGF2 cDNA including the coding sequences for all three CUG and the AUG translational start coding sequences was put under control of a constitutive phosphoglycerate kinase promoter. The Pgk1 polyadenylation sequence was also included in the construct. The construct was microinjected into pronuclear FVB/N oocytes. Production of human FGF2 protein was verified by Western blot. Founder lines with stable copy number and transmission of the transgene were identified and line 48 was established.
(J:33064)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:33064 Coffin JD, et al., Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol Biol Cell. 1995 Dec;6(12):1861-73 |
All: |
1 reference(s) |
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