Vmn2r26^tm2Mom
Targeted Allele Detail

Summary

• Symbol: Vmn2r26^tm2Mom
• Name: vomeronasal 2, receptor 26; targeted mutation 2, Peter Mombaerts
• MGI ID: MGI:3722386
• Synonyms: deltaV2r1b-GFP, deltaV2r1b-IRES-tauGFP
• Gene: Vmn2r26 Location: Chr6:124001717-124038994 bp, + strand Genetic Position: Chr6, 59.06 cM
• Alliance: Vmn2r26^tm2Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154507
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6, which encodes seven putative transmembrane helices, was replaced by an IRES-tauGFP cassette. This allele fails to express the endogenous protein but expresses GFP in vomeronasal sensory neurons actively transcribing this locus.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vmn2r26 Mutation: 58 strains or lines available

References

• Original: J:154507 Leinders-Zufall T, et al., Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat Neurosci. 2009 Dec;12(12):1551-8
• All: 1 reference(s)