Or8a1^{tm35(Adrb2)Mom}
Targeted Allele Detail

Summary

• Symbol: Or8a1^{tm35(Adrb2)Mom}
• Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 35, Peter Mombaerts
• MGI ID: MGI:3722388
• Synonyms: beta2AR->M71-IRES-tauGFP
• Gene: Or8a1 Location: Chr9:37641273-37642357 bp, - strand Genetic Position: Chr9, 20.8 cM
• Alliance: Or8a1^{tm35(Adrb2)Mom} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203483
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Or8a1^{tm35(Adrb2)Mom} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Adrb2 (MGI:87938)

• Mutation details: The endogenous coding sequence for this olfactory receptor was replaced with the coding sequence for beta 2 adrenergic receptor with an IRES-tauGFP-ANCF cassette inserted 3 nucleotides after the stop codon to yield bicistronic expression of beta 2 adrenergic receptor and GFP in place of this olfactory receptor. The ACNf neomycin selection cassette self-excised during transmission through the male germline leaving a single loxP site. (J:203483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Or8a1 Mutation: 69 strains or lines available

References

• Original: J:203483 Brennan DJ, et al., Serum HE4 as a prognostic marker in endometrial cancer--a population based study. Gynecol Oncol. 2014 Jan;132(1):159-65
• All: 3 reference(s)