Pds5b^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Pds5b^tm1Jmi
• Name: PDS5 cohesin associated factor B; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:3722688
• Synonyms: Psd5b^-
• Gene: Pds5b Location: Chr5:150597204-150734155 bp, + strand Genetic Position: Chr5, 89.61 cM
• Alliance: Pds5b^tm1Jmi page

Pds5a^{Gt(RRM243)Byg}/Pds5a^{Gt(RRM243)Byg} Pds5b^tm1Jmi/Pds5b⁺ and Pds5a^{Gt(RRM243)Byg}/Pds5a⁺ Pds5b^tm1Jmi/Pds5b^tm1Jmi mice display abnormal lens development

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124279
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of the second exon is replaced by a betagal/pgk-neo cassette. The floxed neo was removed via cre mediated recombination. Protein was not detected in mutants by immunoblot analysis. (J:124279)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pds5b Mutation: 100 strains or lines available

References

• Original: J:124279 Zhang B, et al., Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development. 2007 Sep;134(17):3191-201
• All: 3 reference(s)