Rr299391^tm1.1Fwa
Targeted Allele Detail

Summary

• Symbol: Rr299391^tm1.1Fwa
• Name: regulatory region 299391; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:3722842
• Synonyms: Edelta^-, Edeltadelta, Tcrd^tm1Fwa
• Gene: Rr299391 Location: Chr14:54375601-54376904 bp, . strand Genetic Position: Chr14, Syntenic
• Alliance: Rr299391^tm1.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55401
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: A 1085 bp region containing Tcrd enhancer Edelta was replaced with a loxP site flanked neomycin resistance gene cassette, which was subsequently removed via cre-mediated recombination. (J:55401)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr299391 Mutation: 0 strains or lines available

References

• Original: J:55401 Monroe RJ, et al., Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity. 1999 May;10(5):503-13
• All: 5 reference(s)