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Pik3cgtm2Ehi
Targeted Allele Detail
Summary
Symbol: Pik3cgtm2Ehi
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 2, Emilio Hirsch
MGI ID: MGI:3722941
Synonyms: p110gammaCAAX, PikgammaCX
Gene: Pik3cg  Location: Chr12:32223472-32258658 bp, - strand  Genetic Position: Chr12, 13.74 cM, cytoband B
Alliance: Pik3cgtm2Ehi page
Spontaneous skin lesions in Pik3cgtm2Ehi/Pik3cgtm2Ehi mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124856
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe locus encoding the catalytic subunit was replaced with a chimeric minigene containing a mutant form of the human cDNA in which the CAAX motif was added at its 5' end. (J:124856)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3cg Mutation:  59 strains or lines available
References
Original:  J:124856 Costa C, et al., Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase {gamma}. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14354-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory