Ackr3^tm1Fma
Targeted Allele Detail

Summary

• Symbol: Ackr3^tm1Fma
• Name: atypical chemokine receptor 3; targeted mutation 1, Fabienne Mackay
• MGI ID: MGI:3722943
• Synonyms: Cxcr7^lox
• Gene: Ackr3 Location: Chr1:90131702-90143446 bp, + strand Genetic Position: Chr1, 45.28 cM
• Alliance: Ackr3^tm1Fma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124878
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted around exon 2. (J:124878)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ackr3 Mutation: 34 strains or lines available

References

• Original: J:124878 Sierro F, et al., Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
• All: 10 reference(s)