Scp2^tm1Kier
Targeted Allele Detail

Summary

• Symbol: Scp2^tm1Kier
• Name: sterol carrier protein 2, liver; targeted mutation 1, Ann B Kier
• MGI ID: MGI:3722944
• Synonyms: SCP-x^-
• Gene: Scp2 Location: Chr4:107901027-108002168 bp, - strand Genetic Position: Chr4, 50.2 cM
• Alliance: Scp2^tm1Kier page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124895
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. Absence of the protein was confirmed by Western analysis. (J:124895)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scp2 Mutation: 59 strains or lines available

References

• Original: J:124895 Atshaves BP, et al., Effect of SCP-x gene ablation on branched-chain fatty acid metabolism. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G939-51
• All: 1 reference(s)