Bche^tm1Loc
Targeted Allele Detail

Summary

• Symbol: Bche^tm1Loc
• Name: butyrylcholinesterase; targeted mutation 1, Oksana Lockridge
• MGI ID: MGI:3723049
• Synonyms: BChE^-, BChE KO
• Gene: Bche Location: Chr3:73543141-73615748 bp, - strand Genetic Position: Chr3, 33.61 cM, cytoband E3
• Alliance: Bche^tm1Loc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124975
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 891bp of the gene is replaced with a neomycin selection cassette, including 485bp from the 3' end of intron 1 and 406bp from the 5' end of exon 2. The region encoding the entire signal peptide, the translation start site, and the first 102 amino acids of the mature protein is deleted. (J:124975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bche Mutation: 33 strains or lines available

References

• Original: J:124975 Li B, et al., Production of the butyrylcholinesterase knockout mouse. J Mol Neurosci. 2006;30(1-2):193-5
• All: 12 reference(s)