Eqtn^tm1Gar
Targeted Allele Detail

Summary

• Symbol: Eqtn^tm1Gar
• Name: equatorin, sperm acrosome associated; targeted mutation 1, David L Garbers
• MGI ID: MGI:3723138
• Synonyms: SSTM
• Gene: Eqtn Location: Chr4:94795504-94817080 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5
• Alliance: Eqtn^tm1Gar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 4-7 with a neomycin resistance cassette and a thymidine kinase (TK) gene. Western blotting revealed the complete absence of protein in homozygous mutant testes. Immunohistochemical analysis and immunofluorescence confirmed the absence of detectable protein in homozygous mutant sperm. (J:101977, J:219150)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eqtn Mutation: 23 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)