Tg(Prnp-SNCA*A53T)AAub
Transgene Detail
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Symbol: |
Tg(Prnp-SNCA*A53T)AAub |
Name: |
transgene insertion A, Georg Auburger |
MGI ID: |
MGI:3723258 |
Synonyms: |
A53T, Hualpha-Syn (A53T), PrPmtA, PrPmtB |
Transgene: |
Tg(Prnp-SNCA*A53T)AAub Location: unknown
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Alliance: |
Tg(Prnp-SNCA*A53T)AAub page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Prnp-SNCA*A53T)AAub expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SNCA (6622) |
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Mutation details: A construct containing the entire translated portion of human alpha-synuclein, SNCA from position 22 to 515, driven by an ~3.5 kb fragment of the mouse prion protein promoter, Prnp, was generated. The SNCA cDNA was followed by polyadenylation sequences derived from the 3' untranslated region of the boving growth hormone gene. This construct was microinjected into pronuclei of fertilized FVB/N ova.
Transgenic protein expression was detected in the neuropil, with, more rarely, additional protein within neuronal cell bodies and neurites in the brain and motoneurons in the spinal cord. Two lines, A and B, were generated, have both been extensively studied, showing extremely similar phenotypes (J:86222, J:124976).
(J:86222)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:86222 Gispert S, et al., Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci. 2003 Oct;24(2):419-29 |
All: |
14 reference(s) |
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