Gpr39^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gpr39^tm1Lex
• Name: G protein-coupled receptor 39; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3723512
• Gene: Gpr39 Location: Chr1:125604732-125801599 bp, + strand Genetic Position: Chr1, 54.7 cM, cytoband E3
• Alliance: Gpr39^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124913
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRESLacZ reporter and a neo selection cassette replaced a 1051 bp genomic fragment including all but the first 92 bp of exon 1. Quantitative RT-PCR indicated that heterozygote mice expressed about half the level of mRNA as wild-type mice, with no mRNA being detected in homozygote mice. LacZ expression was detected in the stomach, intestines, pancreas and brain of homozygote mice. (J:124913)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr39 Mutation: 28 strains or lines available

References

• Original: J:124913 Moechars D, et al., Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse. Gastroenterology. 2006 Oct;131(4):1131-41
• All: 4 reference(s)