Atf6^tm1.1Rjk
Targeted Allele Detail

Summary

• Symbol: Atf6^tm1.1Rjk
• Name: activating transcription factor 6; targeted mutation 1.1, Randal J Kaufman
• MGI ID: MGI:3723526
• Synonyms: Atf6alpha^-
• Gene: Atf6 Location: Chr1:170532243-170695340 bp, - strand Genetic Position: Chr1, 76.96 cM
• Alliance: Atf6^tm1.1Rjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124971
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was deleted by Cre-mediated recombination to create a truncated protein product of 72 amino acids that lacks any functional elements of the protein. This allele also contains an FRT flanked neo cassette upstream of the deleted exon 4. The absence of protein was confirmed by western blot analysis on mouse embryonic fibroblast cells. Removal of the neo cassette has no effect on the phenotype. (J:124971)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf6 Mutation: 45 strains or lines available

References

• Original: J:124971 Wu J, et al., ATF6alpha Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress. Dev Cell. 2007 Sep;13(3):351-64
• All: 14 reference(s)