Tax1bp1^{GT(RRJ464)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Tax1bp1^{GT(RRJ464)Byg}
• Name: Tax1 (human T cell leukemia virus type I) binding protein 1; gene trap RRJ464, BayGenomics
• MGI ID: MGI:3723593
• Synonyms: TAX1BP1^m
• Gene: Tax1bp1 Location: Chr6:52690714-52743765 bp, + strand Genetic Position: Chr6, 25.7 cM
• Alliance: Tax1bp1^{GT(RRJ464)Byg} page

Mutation origin

• Mutant Cell Line: RRJ464
• Germline Transmission: Earliest citation of germline transmission: J:124968
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector consisting of an En2 splice acceptor and betageo cassette was inserted into the fifth intron of the open reading frame. The truncated protein formed contains exons 1 through 5 and encodes of the SKICH domain but lacks all the coiled-coil and zinc-finger domains. (J:124968)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRJ464	CC799067 ; (MGI Seq Detail)	5' RACE	Chr6:52698281-52710331 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  5 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tax1bp1 Mutation: 38 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:124968 Shembade N, et al., Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J. 2007 Sep 5;26(17):3910-22
• All: 3 reference(s)