Psmb10^tm1Mgro
Targeted Allele Detail

Summary

• Symbol: Psmb10^tm1Mgro
• Name: proteasome (prosome, macropain) subunit, beta type 10; targeted mutation 1, Marcus Groettrup
• MGI ID: MGI:3723600
• Synonyms: beta2i^-, MECL-1^-
• Gene: Psmb10 Location: Chr8:106662360-106665024 bp, - strand Genetic Position: Chr8, 53.06 cM
• Alliance: Psmb10^tm1Mgro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125058
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 5 through 7. Homozygous mice had no protein expression of the gene, as determined by 2D gel electrophoresis of 20S proteasomes purified from spleen and virally infected liver. (J:125058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Psmb10 Mutation: 18 strains or lines available

References

• Original: J:125058 Basler M, et al., An altered T cell repertoire in MECL-1-deficient mice. J Immunol. 2006 Jun 1;176(11):6665-72
• All: 41 reference(s)