Hoxa5^tm1.1Ljea
Targeted Allele Detail

Summary

• Symbol: Hoxa5^tm1.1Ljea
• Name: homeobox A5; targeted mutation 1.1, Lucie Jeannotte
• MGI ID: MGI:3723622
• Synonyms: Hoxa5^floxed
• Gene: Hoxa5 Location: Chr6:52178768-52181437 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa5^tm1.1Ljea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125040
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced downstream of exon 2 and a loxP-frt-PGKneopA-frt in the intron upstream of exon 2. Flp-mediated recombination was used to remove the neo cassette leaving a floxed exon 2. A northern blot confirmed the continued expression of the transcript. (J:125040)

Expression

In Mice Carrying this Mutation:	45 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxa5 Mutation: 28 strains or lines available

References

• Original: J:125040 Tabaries S, et al., Comparative analysis of Hoxa5 allelic series. Genesis. 2007 Apr;45(4):218-28
• All: 9 reference(s)